Protein related to DAN and cerberus is a bone morphogenetic protein antagonist that participates in ovarian paracrine regulation.

Protein Related to DAN and Cerberus (PRDC) is a BMP Antagonist that Participates in Ovarian Paracrine Regulation

Structure of protein related to Dan and Cerberus: insights into the mechanism of bone morphogenetic protein antagonism.

The bone morphogenetic proteins (BMPs) are secreted ligands largely known for their functional roles in embryogenesis and tissue development. A number of structurally diverse extracellular antagonists inhibit BMP ligands to regulate signaling. The differential screening-selected gene aberrative in neuroblastoma (DAN) family of antagonists represents the largest group of BMP inhibitors; however,...

Expression of the Dan gene during chicken embryonic development

The Dan gene was first identified as the putative rat tumor suppressor gene and encodes a protein structurally related to Cerberus and Gremlin in vertebrates. Xenopus DAN, as with Cerberus and Gremlin, was demonstrated to block bone morphogenetic protein (BMP) signaling by binding BMPs, and to be capable of inducing additional anterior structures by ectopic overexpression in Xenopus embryos. DA...

Cloning and expression analysis of the chick DAN gene, an antagonist of the BMP family of growth factors.

Differential screening-selected gene aberrative in neuroblastoma (DAN) is a member of a cystine knot protein family that includes Cerberus and Gremlin. First isolated in a screen to identify genes down-regulated in transformed rat fibroblasts, DAN has subsequently been cloned in Xenopus, mouse, and human. Overexpression of DAN suppresses the transformed phenotype and retards the cell's entry in...

Xenopus Dan, a member of the Dan gene family of BMP antagonists, is expressed in derivatives of the cranial and trunk neural crest

Dan is the founding member of the Dan family of secreted cytokines. All members of this family--which includes Gremlin, Cerberus, Dante, PRDC, and several genes identified as expressed sequence tags in the mouse--characterized to date have been shown to antagonize signaling by the bone morphogenetic protein (BMP) family. During mouse embryogenesis, Dan is expressed in a restricted and dynamic p...